Grayscale has unveiled its top 20 altcoins for 2025, highlighting a strong institutional focus on scalability, decentralized finance (DeFi), and ecosystem-driven growth. New entries like Ethena, Jupiter, and Jito emphasize infrastructure innovations, while projects such as Grass aim to revolutionize web crawling on a massive scale. Investors are advised to prioritize established platforms and conduct thorough research, as institutional interest often signals significant market shifts.